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This is a weekly feature that runs down the week’s top 10 announced funding rounds in the U.S. Check out last week’s biggest funding rounds here.

This was a big week for big checks, both confirmed and reported. Among confirmed rounds, the largest financing went to fintech provider Ramp, which landed $500 million at a $22.5 billion valuation to scale its visions around agentic AI. The next-largest financings went to MapLight Therapeutics, a developer of medicines for brain disorders, and Ambience Healthcare, a healthcare AI startup.

As for giant deals that were reported but not officially closed, Anthropric was said to be close to finalizing a round of up to $5 billion led by Iconiq Capital that would push its valuation all the way to $170 billion.

1. Ramp, $500M, fintech: New York-based Ramp, a provider of financial products and tools for businesses to automate finance tasks, raised $500 million at a $22.5 billion valuation. Iconiq Capital led the Series E financing, which brings total equity funding to date to $1.9 billion.

2. MapLight Therapeutics, $372.5M, biopharma and neuroscience: MapLight Therapeutics, a biopharma startup developing medicines for brain disorders, announced that it raised $372.5 million in Series D funding. Forbion and Goldman Sachs Alternatives co-led the financing for the 7-year-old, Redwood City, California-based company.

3. Ambience Healthcare, $243M, healthcare AI: Ambience Healthcare, an AI platform for healthcare systems to use in documentation, coding and clinical documentation, raised $243 million in a Series C round. Oak HC/FT and Andreessen Horowitz led the financing for the San Francisco-based company.

4. Quince, $200M, fashion: Quince, an affordable luxury brand online retailer, raised $200 million at a valuation of more than $4.5 billion, according to a report from Bloomberg. Iconiq Capital reportedly led the San Francisco-based company’s latest financing.

5. Observe, $156M, AI enterprise software: San Mateo, California-based Observe, a provider of AI-enabled observability tools for businesses, raised $156 million in a Series C funding round led by Sutter Hill Ventures. The financing brings funding to date for the 8-year-old company to more than $460 million, per Crunchbase data.

6. (tied) Motive, $150M, fleet management: San Francisco-based Motive, a provider of fleet tracking and driver safety software, raised $150 million in a new funding round led by Kleiner Perkins. The 12-year-old company is also reportedly taking steps toward an IPO.

6. (tied) Anaconda, $150M, AI software: Anaconda, a provider of AI tools for businesses using Python and open source applications, announced it raised over $150 million in a Series C funding round led by Insight Partners. The Austin, Texas-based company said it currently operates profitably with over $150 million in annual recurring revenue as of July.

8. Artbio, $132M, radiopharmaceuticals: Cambridge, Massachusetts-based Artbio, a clinical-stage radiopharmaceutical startup developing therapies (ARTs) to treat a range of cancers, raised $132 million in a Series B round that included Sofinnova Investments and B Capital as lead investors.

9. Fal, $125M, generative media: San Francisco-based Fal, a startup offering a generative image, video and audio platform for developers, raised $125 million in a Series C led by Meritech Capital Partners. The 4-year-old company said it has seen revenue increase 60x in the past 12 months.

10. Oxide Computer Co., $100M, cloud infrastructure: Oxide Computer Co., a developer of cloud infrastructure for on-premises computing, raised $100 million in a Series B round led by US Innovativr Technology. Founded in 2019, the Emeryville, California-based company has raised over $260 million to date, per Crunchbase data.

Methodology

We tracked the largest announced rounds in the Crunchbase database that were raised by U.S.-based companies for the seven-day period of July 26-Aug. 1. Although most announced rounds are represented in the database, there could be a small time lag as some rounds are reported late in the week.

Illustration: Dom Guzman